Does the search for one's raison d’être (or ikigai, Dharma etc.) every really end?

Does the search for one's raison d’être (ikigai, Dharma, calling etc.) every really end? And if so how do you know when you've found it? For years I've been struggling with finding a "calling," my path in life, some clear utilization of a special skill I possess and I feel no where closer to finding it. I remember watching the show Roadtrip Nation a few years ago, it was basically college aged kids who would travel around on a road trip and interview inspiring people who've found success and their niche in the world. The show really got me thinking and it's stuck with me. Sure there's stuff I really enjoy doing but how do you know if a career or lifestyle is right for you?

This may just be post New Years angst but these are just some thought kicking around my head lately.